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The ameliorating effects of melatonin and vitamin C plus vitamin E were examined histologically and biochemically in lung tissues in rats exposed to chlorpyriphos-ethyl CE. Tissue samples of lungs were taken by using appropriate techniques for biochemical and histological examinations under anesthesia at the twenty-fourth hours of CE administration, at the end of the sixth day of the experiment.
Lungs were examined histologically at the end of sixth day. There were remarkable changes in the histomorphology of peribronchial and perivascular area in the lung of rats treated with CE. These were infiltration of mononuclear cells such as lymphocytes, plasmocytes, macrophages , hyperplasia of type II pneumocyte, and thickened and increased connective tissue. These suggest that CE increases lipid peroxidation and decreases antioxidant enzymes activities and AOP due to increasing oxidative stress induced by CE, and high doses of vitamin C plus vitamin E and melatonin considerably reduce CE toxicity in lung tissues of rats.
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of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Full text links Cite Display options Display options. Abstract The ameliorating effects of melatonin and vitamin C plus vitamin E were examined histologically and biochemically in lung tissues in rats exposed to chlorpyriphos-ethyl CE. Similar articles Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidants. Oncu M, et al. Hum Exp Toxicol. PMID: In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats.
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Epub Dec 8. See all "Cited by" articles. MeSH terms Animals Actions. Chlorpyrifos Actions. Lipid Peroxidation Actions. Male Actions. Rats Actions. Rats, Wistar Actions. Substances Antioxidants Actions. Organothiophosphorus Compounds Actions. Vitamin E Actions. Melatonin Actions. Ascorbic Acid Actions. Full text links [x] Elsevier Science. Copy Download.Vitamin c melatonin
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